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apalutamide will decrease the extent or influence of diazepam by influencing hepatic enzyme CYP2C19 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a solid CYP2C19 inducer, with drugs which might be CYP2C19 substrates may result in reduce exposure to those drugs.Just before use, instruct person administering diazepam intra